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Bortezomib intermediate 114457-94-2

【Alias】(S) -3-phenyl-2-[(pyrazine-2-carbonyl) amino] propionic acid (Bortezomib intermediate)
【Catalogue Number】AP0105
【CAS #】 114457-94-2
【Molecular Formula】C14H13N3O3
【Molecular Weight】271.3
English Name : Bortezomib intermediate 114457-94-2
CAS# : 114457-94-2
产品描述
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Alias

(S) -3-phenyl-2-[(pyrazine-2-carbonyl) amino] propionic acid (Bortezomib intermediate)

Catalog Number

AP0105

CAS #

114457-94-2

Molecular Formula

C14H13N3O3

Molecular Weight

271.3

Structural Formula

威智医药

Product Introduction

CAS 114457-94-2

N- (2-pyrazinylcarbonyl) -L-phenylalanine, the English name is N- (2-Pyrazinylcarbonyl) -L-phenylalanine, and the American Chemical Abstract Registration Number is cas 114457-94- 2.

N- (2-pyrazinylcarbonyl) -L-phenylalanine (CAS 114457-94-2) is an intermediate of bortezomib. Bortezomib is a reversible inhibitor of 26S proteasome chymotrypsin-like activity in mammalian cells. Proteolysis can affect the cascade of multilevel signals in the cell, and this damage to the normal intracellular environment can lead to cell death. Inhibition of the 26S proteasome prevents hydrolysis of specific proteins. In vitro tests have proven that bortezomib is cytotoxic to many types of cancer cells. Preclinical tumor model in vivo tests have demonstrated that bortezomib can delay tumor growth, including multiple myeloma. Bortezomib can be used in the treatment of patients with multiple myeloma.

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