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Bortezomib pinanediol ester

【Alias】Butezomipine diol
【Catalogue Number】AP0102
【CAS #】205393-22-2
【Molecular Formula】 C29H39BN4O4
【Molecular Weight】518.46
English Name : Bortezomib pinanediol ester
CAS# : 205393-22-2
产品描述
Parameters

 

Alias

Butezomipine diol

Catalog Number

AP0102

CAS #

205393-22-2

Molecular Formula

C29H39BN4O4

Molecular Weight

518.46

Structural Formula

威智医药

Product Introduction

CAS 205393-22-2

Bortezomib alkyl diol ester, English name is Bortezomib-Pinanediol, American Chemical Abstracts Registration Number is cas 205393-22-2.

Bortezomib oxanediol ester (cas 205393-22-2) is an intermediate of bortezomib. Bortezomib is a reversible inhibitor of 26S proteasome chymotrypsin-like activity in mammalian cells. Proteolysis can affect the cascade of multilevel signals in the cell, and this damage to the normal intracellular environment can lead to cell death. Inhibition of the 26S proteasome prevents hydrolysis of specific proteins. In vitro tests have proven that bortezomib is cytotoxic to many types of cancer cells. Preclinical tumor model in vivo tests have demonstrated that bortezomib can delay tumor growth, including multiple myeloma. Bortezomib can be used in the treatment of patients with multiple myeloma.Administration in June 2012 under the trade name Onbrez®.

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