Alias

Aprepitant Intermediate

Catalog Number

AP0602

CAS #

200000-59-5

Molecular Formula

C₂₇H₂₆F₇NO₅S

Molecular Weight

609.55

Structural Formula

Product Introduction

CAS 200000-59-5

US-DMF No. 27597

(2R, 3S) -2-[(1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) Morpholine p-toluenesulfonic acid salt -morpholine hydrochloride, American Chemical Abstracts Registry Number cas 200000-59-5.

This product (cas 200000-59-5) is an intermediate of aprepitant. Aprepitant was the first neurokinin approved by the US FDA in 2003. (NK-1) receptor blocker, which blocks the action of substance P by binding to the NK-1 receptor (mainly present in the central nervous system and its periphery). This product can cross the blood-brain barrier and occupy the NK-1 receptor in the brain. It has selectivity and high affinity, and has a high affinity for NK. 2 and NK-3 receptor affinity is very low. At the same time, this product has a low affinity for the targets of other drugs (such as dopamine receptors, 5 HT receptors) for the treatment of chemotherapy-induced nausea and vomiting symptoms.