Product

News Center

Aprepitant Intermediate155742-64-6

【Alias】Aprepitant Intermediate
【Catalogue Number】AP0603
【CAS #】155742-64-6
【Molecular Formula】C4H8ClN3O2
【Molecular Weight】165.58
English Name : Aprepitant Intermediate
CAS# : 155742-64-6
产品描述
Parameters

 

Alias

Aprepitant Intermediate

Catalog Number

AP0603

CAS #

155742-64-6

Molecular Formula

C4H8ClN3O2

Molecular Weight

165.58

Structural Formula

威智医药

Product Introduction

CAS 155742-64-6

CAS 155742-64-6 methyl 2- (2-chloro-1-ethylene) hydrazide formate, English name N-Methylcarbonyl-2-chloro-acetamidrazone hydrochloride, American Chemical Abstracts Registry number cas 155742-64-6.

This product (cas 155742-64-6) is an intermediate of aprepitant. Aprepitant was the first neurokinin approved by the US FDA in 2003. (NK-1) receptor blocker, which blocks the action of substance P by binding to the NK-1 receptor (mainly present in the central nervous system and its periphery). This product can cross the blood-brain barrier and occupy the NK-1 receptor in the brain. It has selectivity and high affinity, and has a high affinity for NK. 2 and NK-3 receptor affinity is very low. At the same time, this product has a low affinity for the targets of other drugs (such as dopamine receptors, 5 HT receptors) for the treatment of chemotherapy-induced nausea and vomiting symptoms.

Scan the QR code to read on your phone
We could not find any corresponding parameters, please add them to the properties table
search
Confirm
Close