- Active Pharmaceutical Ingredients
- Varenicline tartrate
- Aprepitant, Fosapitant Intermediates
- Fosaprepitant Dimeglumine
- Vildagliptin
- Efinaconazole
- Luliconazole Intermediate
- Gadoterate Meglumine
- Succinyl Alcohol Intermediate
- Mirabillon Intermediate
- Atazanavir Intermediate
- Intermediate
- Varenicline tartrate
- Aprepitant 287930-73-8
- Aprepitant 127852-28-2
- Aprepitant 287930-75-0
- Aprepitant 200000-59-5
- Aprepitant 155742-64-6
- Aprepitant 252742-72-6
- Fosaprepitant Dimeglumine 990-91-0
- Fosaprepitant Dimeglumine 265121-01-5
- Vildagliptin 207557-35-5
- Vildagliptin 702-82-9
- Efinaconazole 144230-50-2
- Efinaconazole 133775-25-4
- Efinaconazole 127000-90-2
- Gadoterate Meglumine
- Mirabegron
- Luliconazole 98873-55-3
- Luliconazole 126534-31-4
- Atazanavir sulfate
- Bortezomib 179324-87-9
- Bortezomib 114457-94-2
- Bortezomib 205393-22-2
- Brinzolamide
- Rivaroxaban Intermediate 446292-08-6
- Rivaroxaban Intermediate 446292-07-5
- Cinacalcet Hydrochloride 1005450-55-4
- Cinacalcet Hydrochloride 585-50-2
- Eletriptan Intermediate
- Indacaterol intermediate 312753-53-0
- Indacaterol intermediate 173140-90-4
- Sitagliptin Intermediate
- Fosanavir Calcium Intermediate
Popular information
Bortezomib intermediate
【Catalogue Number】AP0101
【CAS #】 179324-87-9
【Molecular formula】C17H29BF3NO4
【Product Introduction】(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methyl bridge-1,3 ,2-Benzodioxyborane-2-methylamine 2,2,2-trifluoroacetate, English name is (1R)-(S)-Pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1-boronate , The American Chemical Abstracts Registry number is cas 179324-87-9.
Bortezomib intermediate
Alias Bortezomib Intermediate
Catalog number AP0101
CAS # 179324-87-9
Molecular formula C17H29BF3NO4
Molecular weight 379.22
Structural formula
Product introduction
CAS 179324-87-9 (aR, 3aS, 4S, 6S, 7aR) -hexahydro-3a, 8,8-trimethyl-alpha- (2-methylpropyl) -4,6-methyl bridge-1 , 3,2-benzodioxorane-2-methylamine 2,2,2-trifluoroacetate, the English name is (1R)-(S) -Pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1 -boronate, American Chemical Abstracts Registry Number cas 179324-87-9.
This product salt (cas 179324-87-9) is an intermediate of bortezomib. Bortezomib is a reversible inhibitor of 26S proteasome chymotrypsin-like activity in mammalian cells. Proteolysis can affect the cascade of multilevel signals in the cell, and this damage to the normal intracellular environment can lead to cell death. Inhibition of the 26S proteasome prevents hydrolysis of specific proteins. In vitro tests have proven that bortezomib is cytotoxic to many types of cancer cells. Preclinical tumor model in vivo tests have demonstrated that bortezomib can delay tumor growth, including multiple myeloma. Bortezomib can be used in the treatment of patients with multiple myeloma.
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