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Bortezomib intermediate

【Alias】Bortezomib Intermediate
【Catalogue Number】AP0101
【CAS #】 179324-87-9
【Molecular formula】C17H29BF3NO4
【Product Introduction】(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methyl bridge-1,3 ,2-Benzodioxyborane-2-methylamine 2,2,2-trifluoroacetate, English name is (1R)-(S)-Pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1-boronate , The American Chemical Abstracts Registry number is cas 179324-87-9.
English Name : Bortezomib intermediate
CAS# : 179324-87-9
产品描述
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Bortezomib intermediate

 

 (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine, 2,2,2-trifluoroacetate
CAS 179324-87-9

Alias Bortezomib Intermediate

Catalog number AP0101

CAS # 179324-87-9

Molecular formula C17H29BF3NO4

Molecular weight 379.22

Structural formula

威智医药

Product introduction

CAS 179324-87-9 (aR, 3aS, 4S, 6S, 7aR) -hexahydro-3a, 8,8-trimethyl-alpha- (2-methylpropyl) -4,6-methyl bridge-1 , 3,2-benzodioxorane-2-methylamine 2,2,2-trifluoroacetate, the English name is (1R)-(S) -Pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1 -boronate, American Chemical Abstracts Registry Number cas 179324-87-9.

This product salt (cas 179324-87-9) is an intermediate of bortezomib. Bortezomib is a reversible inhibitor of 26S proteasome chymotrypsin-like activity in mammalian cells. Proteolysis can affect the cascade of multilevel signals in the cell, and this damage to the normal intracellular environment can lead to cell death. Inhibition of the 26S proteasome prevents hydrolysis of specific proteins. In vitro tests have proven that bortezomib is cytotoxic to many types of cancer cells. Preclinical tumor model in vivo tests have demonstrated that bortezomib can delay tumor growth, including multiple myeloma. Bortezomib can be used in the treatment of patients with multiple myeloma.

 

 

 

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