Alias

7-[(3R) -3-amino-1-oxo-4- (2,4,5-trifluorophenyl) butyl] -5,6,7,8-tetrahydro-3-trifluoro Methyl-1,2,4-triazolo [4,3-a] pyrazine phosphate monohydrate

Catalog Number

AP2401

CAS #

654671-77-9

Molecular Formula

C₁₆H₂₀F₆N₅O₆P

Molecular Weight

523.32

Structural Formula

Product Introduction

CAS 654671-77-9

US-DMF No. 29226

Sitagliptin phosphate monohydrate, the English name is Sitagliptin Phosphate Monohydrate, and the American Chemical Abstracts Registration Number is cas 654671-77-9.

Sitagliptin phosphate monohydrate (cas 654671-77-9) is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which controls blood glucose levels by protecting endogenous incretin and enhancing its effect. Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) are incretins released against dietary intake. GLP-1 and GIP can increase insulin synthesis and release from islet β cells through intracellular signaling pathways. GLP-1 can also reduce glucagon secretion from islet α cells and reduce liver glucose production. However, both GLP-1 and GIP are rapidly metabolized by DPP-4, resulting in a loss of their insulinotropic effects. This medicine inhibits the degradation of incretin by DPP-4, so it can enhance the functions of GLP-1 and GIP, increase the release of insulin and reduce the glucagon level in the circulation (this effect is glucose-dependent). This drug selectively inhibits DPP-4 and has no inhibitory activity on DPP-8 or DPP-9. Can be used for the treatment of type 2 diabetes.